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Lack of blockade of PNU-120596–induced antinociception in the formalin test by naloxone. Mice were treated with s.c. naloxone 15 minutes prior to PNU-120596 (4 mg/kg i.p.) injection. They were tested 15 minutes after the second injection in the formalin test. The time spent licking the injected paw was recorded during the early (A) and late phase (B) after formalin injection. Each group represents the mean ± S.E. of six to eight mice. *P < 0.05 versus vehicle-vehicle group.
