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Blockade of PNU-120596's antinociceptive effect after i.t. MLA administration in the phase 2 of the formalin test. Mice were treated with either PNU-120596 (4 mg/kg i.p.) or vehicle (i.p.) 15 minutes prior to MLA (10 μg/5 μl i.t.) injection and were tested 5 minutes later in the formalin test. Each bar represents the mean ± S.E.M. for each group of six to eight mice. *P < 0.05 versus vehicle-vehicle group; #P < 0.05 versus PNU-120596 (4 mg/kg). PNU, PNU-120596; Veh, vehicle.
