Fig. 8.

Effects of MEK inhibitor U0126 on PNU-120596–induced antinociception in the formalin test. Mice were treated with the MEK inhibitor U0126 (0.04, 0.2, and 1 µg/mouse i.t.) or vehicle 5 minutes prior to PNU-120596 (4 mg/kg. i.p.) injection. Mice were tested 15 minutes later during phase 2 of the formalin test. Each bar represents the mean ± S.E.M. for each group of six to eight mice. *P < 0.05 versus vehicle-vehicle group; ^#P < 0.05 versus PNU-120596 (4 mg/kg). PNU, PNU-120596; Veh, vehicle.