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. 2013 Jan;41(1):197–205. doi: 10.1124/dmd.112.048595

TABLE 2.

Statistical comparisons between treatment groups by GeoMean ratio

Parameter Statistical Test dl-MPH + Ethanol
to dl-MPH d-MPH + Ethanol
to
d-MPH dl-MPH + Ethanol
to
d-MPH + Ethanol dl-MPH
to
d-MPH
K d-MPH GeoMean Ratio 1.00 1.03 0.95 0.98
90% CI 0.92–1.08 0.95–1.11 0.88–1.03 0.91–1.06
P value 0.928 0.582 0.283 0.667
Cmax d-MPH GeoMean Ratio 1.22 1.15 0.97 0.91
90% CI 1.13–1.32 1.06–1.24 0.90–1.04 0.84–0.98
P value <.001 0.005 0.462 0.041
AUC0-inf GeoMean Ratio 1.21 1.14 1.01 0.95
90% CI 1.14–1.30 1.07–1.22 0.94–1.08 0.89–1.01
P value <0.001 0.001 0.846 0.193
AUC(0.5–2 hours) d-MPH GeoMean Ratio 1.72 0.95 1.09 0.6
90% CI 1.32–2.24 0.73–1.24 0.84–1.42 0.46–0.79
P value 0.001 0.75 0.57 0.002
K l-MPH GeoMean Ratio 1.26
90% CI 1.08–1.48
P value 0.018
Cmax l-MPH GeoMean Ratio 1.78
90% CI 1.50–2.11
P value <0.001
AUC0-inf l-MPH GeoMean Ratio 1.5
90% CI 1.18–1.91
P value 0.009
Cmax Ethanol GeoMean Ratio 0.99
90% CI 0.91–1.06
P value 0.744
AUC0–12 hours Ethanol GeoMean Ratio 0.99
90% CI 0.90–1.08
P value 0.795