TABLE 4.

Pentobarbital-induced sleeping time in WT and Cyp2a(4/5)bgs-null (null) mice

Adult male and female mice (four in each group; 2 to 3 months old) were treated with pentobarbital (in phosphate-buffered saline) at a dose of 60 mg/kg i.p. The lengths of time between drug administration and the loss and the subsequent recovery of righting reflex were recorded. Values presented are means ± S.D.

Mouse	Sleep Latency	Sleep Time
	min
WT, male	4.3 ± 0.4	51 ± 5
Null, male	4.2 ± 0.5	90 ± 12a
WT, female	4.0 ± 0.5	53 ± 8
Null, female	4.1 ± 0.6	85 ± 8a

WT, wild type.

^aSignificantly greater than the WT group, P < 0.01 (Student’s t test).