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A tentative model for the CYP2B4-CYP2E1 interaction. Inhibition of CYP2B4 activity may arise from the formation of a CYP2E1-CYP2B4 complex. CPR is believed to be highly flexible (Hamdane et al., 2009; Xia et al., 2011) in solution and a CYP2E1-CYP2B4 complex could trap CPR in a particular conformation that makes it more favorable for CYP2E1, instead of CYP2B4, to bind at a functional site on CPR with a higher affinity than CYP2E1 or CYP2B4 alone.
