TABLE 1.

Effect of lopinavir exposure for 24 h, in the presence or absence of ritonavir, on sandwich-cultured rat hepatocyte viability

Day 3 sandwich-cultured rat hepatocytes were treated for 24 h with LPV in the absence or presence of 5 µM ritonavir (LPV/r). Data represent mean ± SEM (n = 3 livers in triplicate).

	LPV		LPV/r
	Viability (% Control)
LPV Dosing Concentration (µM)	LDH Assay	ATP Assay	LDH Assay	ATP Assay
5	99 ± 1	102 ± 15	99 ± 1	81 ± 7
10	100 ± 1	105 ± 7	99 ± 1	80 ± 7
25	99 ± 1	101 ± 1	98 + 1	79 ± 4
50	98 ± 2	81 ± 22	88 ± 8	68 ± 25