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Potentiation by ACPD and PMA is nonadditive. (A) AMPA steady-state currents were recorded from an oocyte expressing GluK2/GluK5/mGlu1. After exposure to 100 μM ACPD, the cell was subsequently treated with 50 nM PMA. Prior exposure to ACPD resulted in a much lower response to PMA. (B) quantification under the same conditions as in A demonstrates that the potentiation of ACPD and PMA is not additive (n ≥ 4).
