Table 2.
Measurements by observer 2 (mean ± sd), inter-observer repeatability (Obs. 1: 2. meas.) and variation (N = 30) for FA and ADC (10-3mm2/s)
| |
|
Circular ROI |
Freehand ROI |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Region | Parameter | Mean ± SD | ICC | p | CV(%) | Mean ± SD | ICC | p | CV(%) |
| Basal pons |
FA |
0.705 ± 0.044 |
0.44 |
0.004* |
8.6 |
0.621 ± 0.061 |
0.73 |
< 0.001* |
9.2 |
| |
ADC |
0.726 ± 0.069 |
0.24 |
0.226 |
8.9 |
0.730 ± 0.080 |
0.01 |
0.487 |
8.4 |
| Cerebral peduncle |
FA |
0.850 ± 0.035 |
0.62 |
0.006 |
4.9 |
0.788 ± 0.062 |
0.14 |
0.319 |
6.4 |
| |
ADC |
0.706 ± 0.048 |
0.56 |
0.018 |
7.0 |
0.772 ± 0.070 |
0.49 |
0.008 |
6.8 |
| Internal capsule, post |
FA |
0.767 ± 0.046 |
0.67 |
< 0.001* |
5.6 |
0.728 ± 0.036 |
0.80 |
< 0.001* |
5.0 |
| |
ADC |
0.696 ± 0.034 |
0.63 |
0.001* |
4.2 |
0.693 ± 0.021 |
0.84 |
< 0.001* |
2.8 |
| Corona radiata |
FA |
0.508 ± 0.038 |
0.54 |
0.023 |
8.6 |
0.515 ± 0.047 |
0.78 |
< 0.001* |
9.0 |
| |
ADC |
0.648 ± 0.030 |
0.64 |
0.005 |
4.5 |
0.665 ± 0.025 |
0.93 |
< 0.001* |
3.6 |
| Centrum semiovale |
FA |
0.501 ± 0.067 |
0.64 |
0.004* |
14.5 |
0.509 ± 0.051 |
0.47 |
0.007 |
9.9 |
| |
ADC |
0.700 ± 0.042 |
0.75 |
< 0.001* |
6.0 |
0.693 ± 0.024 |
0.86 |
< 0.001* |
3.3 |
| Uncinate fasciculus |
FA |
0.529 ± 0.060 |
0.62 |
0.007 |
11.7 |
0.517 ± 0.050 |
0.74 |
< 0.001* |
8.5 |
| |
ADC |
0.779 ± 0.036 |
0.55 |
0.018 |
4.4 |
0.768 ± 0.025 |
0.84 |
< 0.001* |
3.7 |
| Forceps minor |
FA |
0.545 ± 0.057 |
0.64 |
0.004* |
12.0 |
0.499 ± 0.051 |
0.83 |
< 0.001* |
9.5 |
| |
ADC |
0.762 ± 0.046 |
0.17 |
0.319 |
5.1 |
0.757 ± 0.029 |
0.88 |
< 0.001* |
3.7 |
| Ant corona radiata |
FA |
0.551 ± 0.073 |
0.84 |
< 0.001* |
13.7 |
0.497 ± 0.040 |
0.86 |
< 0.001* |
8.3 |
| |
ADC |
0.754 ± 0.029 |
0.45 |
0.060 |
3.8 |
0.748 ± 0.024 |
0.82 |
< 0.001* |
3.5 |
| CC genu |
FA |
0.836 ± 0.034 |
0.80 |
< 0.001* |
4.2 |
0.785 ± 0.051 |
0.51 |
0.013 |
5.3 |
| |
ADC |
0.765 ± 0.044 |
0.80 |
< 0.001* |
6.2 |
0.846 ± 0.069 |
0.37 |
0.012 |
7.3 |
| CC body |
FA |
0.696 ± 0.057 |
0.39 |
0.066 |
6.7 |
0.654 ± 0.069 |
0.62 |
0.003* |
9.8 |
| |
ADC |
0.821 ± 0.164 |
0.61 |
0.008 |
15 |
0.862 ± 0.114 |
0.65 |
0.001* |
12.2 |
| CC splenium |
FA |
0.864 ± 0.047 |
0.90 |
< 0.001* |
5.6 |
0.838 ± 0.043 |
0.88 |
< 0.001* |
5.2 |
| ADC | 0.717 ± 0.038 | 0.81 | < 0.001* | 5.4 | 0.739 ± 0.039 | 0.80 | < 0.001* | 5.5 | |
* = the statistical significance p < 0.05/11 with Bonferroni correction for 11 regions.
ICC = intra-class correlation coefficient; CV = coefficient of variation.