Figure 3. Select B cells undergoing SHM in the periphery of patients with MS are also present in the CSF.

Shown are IgG-VH lineages with predominantly PB-derived IgG-VH, (A and B) suggestive of B cell migration from the CNS to the PB or (C–E) seeding from the PB into the CNS. Blue nodes represent CSF-derived IgG-VH sequences, red nodes represent PB-derived IgG-VH sequences, and green nodes represent identical sequences found in both compartments. For additional information, see the legend of Figure 2.