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. 2012 Nov 19;122(12):4533–4543. doi: 10.1172/JCI63842

Figure 6. Preferential usage of IGHV4 germline segments by IgG-expressing CSF B cells in MS.

Figure 6

(A) Averages of IGHV germline segment usage in (A) MS CSF compared with that in OND CSF and (B) B cell clusters in MS CSF compared with MS PBMCs. (A) IgG-VH using IGHV4-39 (P = 0.04, resampling-based permutation test) and IGHV4-59 or IGHV4-61 (P = 0.01) are significantly overrepresented in MS CSF (also see Supplemental Table 3) compared with OND CSF. (B) Comparisons of IGHV usage in clusters of MS and OND B cells contributing to the CSF reveal overrepresentation of IGHV4-59 or IGHV4-61 in MS (P = 0.02)(also see Supplemental Table 4). IGHV4-39 and IGHV4-4 are marginally overrepresented (P = 0.06 and P = 0.07, respectively). IGHV3-53/66, IGHV3-53 or IGHV3-66; IGHV3-30/33rn, IGHV3-30 or IGHV3-33; IGHV4-59/61, IGHV4-59 or IGHV4-61; IGHV4-30-4/31, IGHV4-30-4 or IGHV4-31. Values shown in the graph are mean ± SEM. *P < 0.05.