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. 2012 Nov 1;122(12):4635–4644. doi: 10.1172/JCI63924

Figure 5. Hif-associated Hamp1 suppression requires erythropoietic activity.

Figure 5

(A) Renal and hepatic Epo (n = 3, 5, and 3, respectively) in control mice and Vhl–/– mutants with or without Cp treatment and liver Hamp1 RNA levels (n = 6, 4, and 3, respectively) in nontreated control, Cp-treated control, and Cp-treated Vhl–/– mutants. Lower panels show Hct, reticulocyte counts, (n = 3 and 4, respectively), serum Epo (n = 3 and 5, respectively), and spleen to body weight ratios in nontreated control and Cp-treated Vhl–/– mice (n = 3 each). (B) Hamp1 mRNA levels in control and Hif2a/Pax3-cre (P3) mutants exposed to chronic hypoxia (10% O2 for 10 days) (n = 3 each) and in thalassemic mice (th3/th3) and control littermates (+/+) (n = 4 each). Shown are mean values ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001, for comparisons with control group or comparison with normoxia. Cp, mice pretreated with Cp; Hx, treatment with 10% O2 for 10 days.