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. 2012 Nov 1;122(12):4675–4679. doi: 10.1172/JCI64526

Figure 1. Functional link between NPRA expression and oxidative markers in human skeletal muscle.

Figure 1

(A) Representative blot of OXPHOS proteins in skeletal muscle of one subject at baseline (Bas) and after training (Post). (B) OXPHOS complex protein expression, (C) mtDNA content, and (D) NPRA and PGC1A gene expression in skeletal muscle of sedentary subjects at baseline and after 8 weeks of aerobic exercise training. (E and F) Gene expression of PRKG1 and PDE5A in primary human myoblasts during the time course of differentiation (n = 3–5). (G) Effect of acute ANP and BNP (1 μM) treatment, and (H) dose-response effect of ANP, on intracellular cGMP levels in differentiated human primary myotubes (n = 4–15). *P < 0.05, **P < 0.01 versus baseline.