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. 2012 Nov 12;122(12):4473–4489. doi: 10.1172/JCI64560

Figure 4. MHC-I restriction of a HERV-K(HML-2)-Env–specific T cell clone.

Figure 4

The MHC-I restriction of the HERV-K(HML-2)-Env–specific T cell clone was determined by testing its responsiveness to a panel of peptide-pulsed BLCLs. Shown are flow cytometry data depicting an example of a lack of recognition of a peptide-pulsed BLCL that did not share any MHC-I alleles with OM9 (top) and recognition of a peptide-pulsed BLCL that was matched on only HLA-A*0301 (bottom). CD107a staining (degranulation) and IFN-γ production were assessed as measures of responsiveness. Numbers represent percentages of cells in each quadrant.