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. 2012 Nov 12;122(12):4344–4361. doi: 10.1172/JCI65053

Figure 2. Nuclear 8-oxo–dG levels in striatum detected by LC-MS/MS analysis.

Figure 2

(A) DARPP32-positive MSNs were still detected on the fourth day of 3-NP exposure. Arrows show that DARPP32 staining was slightly decreased in the Mth1/Ogg1-DKO striatum compared with WT striatum exposed to 3-NP. Scale bar: 50 μm. (B) Nuclear 8-oxo–dG levels in striatum measured by LC-MS/MS analysis. The number of animals examined is 5 for each group. Residues of 8-oxo–dG per 106 nucleotides in nuclear DNA determined by LC-MS/MS are shown as LS means ± SEM. Nuclear 8-oxo–dG levels were not significantly increased in either group after exposure to 3-NP (Student’s t test).