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. 2012 Oct 30;13:576. doi: 10.1186/1471-2164-13-576

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Copyright ©2012 Molnár et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reconstruction of the biosynthesis of triterpenoid sterols and vitamin D₃ in B. brauniiShowa. 36, (S)-2,3-epoxisqualene; 37, cycloartenol; 38, 24-methylenecholesterol; 39, isofucosterol; 40, cholesterol; 41, 25-hydroxyvitamin D₃ (calcidiol). SQLE, squalene monooxygenase; CAS, cycloartenol synthase; SMT, sterol 24-C-methyltransferase; ERG25, methylsterol monooxygenase; CPI1, cycloeucalenol cycloisomerase; CYP51, sterol 14-demethylase; ERG24, Δ-14-sterol reductase; EBP, cholestenol Δ-isomerase; MSMT, 24-methylenesterol C-methyltransferase; SC5DL, lathosterol oxidase; DHCR7, 7-dehydrocholesterol reductase.