Fig. 1.

Effect of Akt gene ablation on insulin-assisted glucose tolerance. Mice were fasted (6 h) and then given an intraperitoneal injection of insulin (18.0 U/kg body wt) and glucose (2 mg/g body wt) as described in the methods. Blood was collected from the tail vein at 0, 15, 30, 45, and 60 min following the insulin-glucose injection and assessed for glucose. The number of mice per group is 4–8. *Akt2^−/− mice are significantly different from Akt1^−/− and wild-type (WT) mice; +Akt1^−/− mice are significantly different from WT mice.