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. 2013 Jan;98(1):41–49. doi: 10.3324/haematol.2012.069815

Figure 2.

Figure 2.

The value of IL-10 SFC derived from monocytes is a versatile biomarker for active chronic GVHD (cGVHD). (A) The numbers of IFN-γ, IL-4, IL-10, and IL-17 SFC are shown in patients with no cGVHD (white column; sample n=41), active cGVHD (black column; n=33), and inactive cGVHD (gray column; n=23). The number of cytokine SFC is shown per 50,000 PBMC. (B) PBMC obtained from seven patients with active cGVHD were separated with magnetic beads using negative selection into six subpopulations of cells before the ELISPOT assay. The data are expressed as mean±SD. The shaded area shows the cut-off value for IL-10 SFC (mean+2SD). **P<0.01.