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. 2013 Jan;98(1):71–78. doi: 10.3324/haematol.2012.066555

Figure 2.

Figure 2.

Log odds ratios measuring the association of baseline prognostic factors with imaging parameters at baseline. DHIM comparisons were limited to the subset of participants with no detected MRI-FLs (n=82 for standard laboratory and imaging variables and n=74 for GEP variables). (A) MBS and MRI. Left: both MBS-OL cut-off points were correlated with both cut-off points for MRI-FL and PET-FL. Among GEP variables, high risk (70-gene model), PR subtype, and CI, all reflecting disease aggressiveness, were significantly linked to more than 2 MBS-OLs. DelTP53 was neutral relative to MBS-OLs. Among standard laboratory prognostic variables, high serum levels of β2M (>5.5 mg/L) were associated with more than 2 MBS-OLs. Middle: for both MRI-FL cut-off points, there were strong positive correlations with MBS-OLs and PET-FLs, but not with PET FL-SUV, EMD, or SUVdiff. Among GEP features, PI and CI positively correlated with MRI-FL >7. Among GEP-defined molecular subgroups, the PR subgroup positively correlated with MRI-FLs. Both MRI-FL cut-off points correlated with high-risk scores from the 70-gene model, but only the higher cut-off point (>7) was linked to high-risk scores from the 80-gene model. Among standard laboratory prognostic variables, CRP had significant positive correlations to MRI-FL >7. Right: for the subset with no MRI-FL, DHIM was associated with increased LDH and β2M. The comparison of GEP-80 risk groups was not possible because of the small number of GEP-80 high-risk subjects. Some parameters could not be estimated due to small sample sizes or association by definition (for example, MRI-FL >7 vs. MRI-FL >0). (B) PET. Left: PET-based FL number was examined for correlations with other imaging parameters, standard laboratory prognostic variables, and GEP variables. At both cut-off points (>0 and >3), PET-FLs had highly significant positive correlations with MBS-OLs and MRI-FLs. GEP-derived variables that were significantly positively associated with PET-FL included high-risk myeloma defined by the 70-gene model as well as PI and CI. Among GEP-defined molecular subgroups, the PR subgroup showed positive correlation and the LB subgroup negative correlation to PET-FLs. Among standard laboratory prognostic variables, elevated CRP and LDH were seen more often with more PET-FLs. Middle: PET FL-SUV was highly associated with more than 3 PET-FLs, high-risk disease (70-gene model), and SUVdiff. Right: PET-EMD was linked to high β2M. Comparison of the CD-1 sub-group versus all other GEP subgroups was not possible because of the small number of CD-1 subjects.