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. 2012 Dec 28;48(6):849–862. doi: 10.1016/j.molcel.2012.11.001

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© 2012 ELL & Excerpta Medica.

Open Access under CC BY 4.0 license

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Demethylation Resistance

(A) Methylation levels for CG dinucleotides within the consensus sequence of IAP1 (top left), IAP2 (bottom left), LINE1A (top right), and LINE1Tf (bottom right). Note that these elements retain substantial levels of methylation across all time points. Outliers are not shown. See also Figure S3.

(B) Methylation levels for resistant CGIs selected with >25% methylation in E13.5 male (left) and female PGCs (right) without an IAP in close proximity (top) or near an IAP (bottom). Note that resistant CGIs with a distance of <2 kb to an IAP show consistently higher methylation levels across all time points, while CGIs without the presence of an IAP show variable methylation levels across all time points. See also Figures S3–S5.

(C) Example figures for resistant CGIs without an IAP in close proximity (left) or with an IAP nearby (right). Each bar represents a single CG dinucleotide.