Table 2.

Risk factors of tumour recurrence

		n	Recurrence-free survival median (95% CI)	Univariate analysis			Multivariate analysis
				P	HR	95% CI	P	HR	95% CI
Age	>65	136	38.7 (28.0–51.1)	0.992
	≤65	144	32.4 (26.7–44.9)
Gender	Male	210	35.6 (25.8–47.2)	0.966
	Female	70	37.9 (25.8–50.0)
HBsAg	+	59	41.0 (26.7–69.9)	0.251
	−	221	34.3 (28.8–42.8)
HCV-Ab	+	174	29.1 (24.0–37.9)	0.003	1.64	1.18–2.30	0.001	1.79	1.27–2.52
	−	106	55.5 (35.6–69.9)
Child–Pugh	B	245	38.7 (28.9–50.4)	0.608
	A	35	32.1 (24.0–37.9)
Background liver	LC	129	50.4 (28.9–80.6)	0.017	1.46	1.07–2.00	0.027	1.44	1.04–1.99
	non LC	151	32.4 (24.7–38.9)
Maximum diameter	>2 cm	202	35.6 (27.3–48.9)	0.195	1.25	0.98–1.80	0.631
	≤2 cm	78	38.7 (28.8–64.7)
Gross classification a	SNEG or CM	102	27.3 (21.0–48.3)	0.246
	VN or SN	175	40.7 (32.4–55.5)
Capsule formation	+	305	50.4 (33.3–69.4)	0.084	0.74	0.53–1.02	0.062
	−	78	28.8 )24.0–35.6)
Differentiation	mod/por	54	29.9 (18.8–51.1)	0.433
	Wel	219	37.9 (28.9–50.0)
Microvascular invasion	+	60	28.8 (14.9–40.7)	0.022	1.57	1.07–2.26	0.049	1.50	1.02–2.22
	−	220	38.1 (30.0–55.5)
Micrometastases	+	24	12.9 (6.6–25.8)	0.004	2.24	1.33–3.57	0.004	2.09	1.26–3.46
	−	256	38.1 (30.3–48.9)
AFP (ng/ml)	>20	125	35.8 (32.1–40.7)	0.189	1.22	0.90–1.67	0.751
	≤20	155	41.0 (32.1–59.4)
DCP (mAu/ml)	>100	79	24.0 (16.9–58.1)	0.037	1.44	1.02–2.00	0.007	1.64	1.14–2.36
	<100	201	38.9 (30.3–50.0)
Types of resection	Non-anatomic	96	28.8 (22.3–35.8)	0.011	1.51	1.10–2.07	0.017	1.48	1.07–2.03
	Anatomic	184	47.2 (30.4–64.4)
Transfusion	+	7	37.9 ( 6.0–65.7)	0.630	1.29	0.40–3.05
	−	259	35.9 (29.1–47.2)
Tumour exposure b	+	65	25.5 (19.6–39.9)	0.012	1.57	1.11–2.20	0.200
	−	215	38.1 (30.0–57.9)
Surgical margin +1 mm				0.065	0.98	0.95–1.00	0.857

Boldfaced entries represent significant factors in the final model.

^aClassification of the Liver Cancer Study Group of Japan.³⁰

^bExposure of the tumour capsule on the cut surface of the liver.

AFP, alfa-fetoprotein; DCP: des-gamma carboxyprothrombin; LC, liver cirrhosis; SNEG: simple nodular type with extranodular growth; CM, confluent multinodular type; VN, vague nodular type; SN, simple nodular type, wel/mod/por: well/moderately/poorly differentiated hepatocelluar carcinoma; HR, hazard ratio; 95% CI, 95% confidence interval.