Table 3.

Adjusted Cox proportional hazards regression model for 5-year disease-specific survival (DSS) and overall survival (OS) in patients with stage I gallbladder carcinoma

Variable: reference	Variables: comparison	5-year disease-specific survival		5-year overall survival
		HR (95% CI)	P-value	HR (95% CI)	P-value
Age: <50 years	50–59 years	1.628 (0.889–2.981)	0.114	1.260 (0.771–2.059)	0.357
	60–69 years	1.922 (1.084–3.408)	0.025	1.501 (0.947–2.379)	0.084
	70–79 years	1.923 (1.102–3.355)	0.021	1.951 (1.256–3.031)	0.003
	>80 years	2.608 (1.496–4.548)	0.001	3.023 (1.949–4.687)	<0.001
Race: White	Black	N/A	N/A	1.629 (1.236–2.148)	<0.005
	Other	N/A	N/A	0.888 (0.688–1.144)	0.357
	Unknown	N/A	N/A	0.000 (0.000–0.000)	0.956
T1 sub-stage: T1a	T1b	1.311 (0.989–1.739)	0.060	1.240 (0.994–1.547)	0.057
	T1NOS	2.470 (1.845–3.307)	<0.001	1.931 (1.524–2.448)	<0.001
Surgery type: cholecystectomy alone	C + LN	0.501 (0.353–0.710)	0.001	0.638 (0.488–0.834)	0.001
	RC	0.410 (0.218–0.771)	0.006	0.742 (0.490–1.122)	0.157
Grade: well differentiated	Moderate	1.483 (1.104–1.991)	0.009	1.239 (0.985–1.558)	0.067
	Poor	2.696 (1.977–3.675)	<0.001	2.107 (1.642–2.704)	<0.001
	Undifferentiated	3.430 (1.885–6.242)	<0.001	2.233 (1.259–3.963)	0.006
	Unknown	1.193 (0.843–1.688)	0.318	1.048 (0.798–1.375)	0.737
Histology: adenocarcinoma	Neuroendocrine	0.129 (0.018–0.933)	0.043	0.316 (0.116–0.865)	0.025
	Papillary	0.505 (0.338–0.756)	<0.009	0.594 (0.440–0.803)	<0.001
	Other	1.997 (1.431–2.789)	<0.001	1.734 (1.279–2.350)	<0.004

HR, hazard ratio; 95% CI, 95% confidence interval; N/A, not available; T1NOS, tumour stage I not otherwise specified; C + LN, cholecystectomy plus lymph node dissection; RC, radical cholecystectomy.