Table 4.

Clinical studies of patients with stage I gallbladder carcinoma published in the last 21 years

Authors, year	Patients, n	Overall survival			Comment/treatment
		Median, months	5 years, %	10 years, %
Wibbenmeyer et al., 199531	2	16a
Yamaguchi et al., 199632	2	Not mentioned			100% at 2 years
Mingoli et al., 199733	2	6.5
Kraas et al., 20029	2		100%a
Arnaud et al., 199529	4		100%
Shimada et al., 19973	4		100%		RC
Donohue et al., 19904	6		100%		Cholecystectomy, RC
Sarli et al., 200034	6	24a			Cholecystectomy
Gall et al., 199135	7	100	57%
North et al., 199836	7	24
Whalen et al., 200137	11	19.5
Kang et al., 200738	11	Not mentioned			Cholecystectomy
Tsukada et al., 199711	15	76	91%		RC
Sun et al., 200530	15		100%		Cholecystectomy
Cho et al., 201014	18	Not mentioned			Cholecystectomy
de Aretxabala et al., 199739	24		87.50%		Cholecystectomy, RC
Suzuki et al., 20008	25		96%		Cholecystectomy
Wakai et al., 20017	25	90–95		87%	T1b/cholecsytectomy, RC
Chan et al., 200640	33		87%		Cholecystectomy
Shirai et al., 199210	40		100%		Cholecystectomy, RC
Goetze & Paolucci, 201015	118	56	49–71%		Cholecystectomy, RC
Ogura et al., 19915	366		78%		RC
Downing et al., 201112	683	33–93			Cholecystectomy, C + LN, RC

^aApproximate.

C + LN, cholecystectomy plus lymph node dissection; RC, radical cholecystectomy.