Table 2.
Primary and secondary renal function outcomes
|
Delay after heart transplantation |
Low-dose group |
Standard-dose group |
P value† |
||
|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | ||
| Creatinine level |
|
|
|
|
|
| At baseline |
47 |
125(44)* |
48 |
127(48) |
0.59 |
| Low versus standard cyclosporine A (CsA) regimen maintained: |
|
|
|
|
--- |
| At 0.5 month |
47 |
101(30) |
47 |
116(62) |
--- |
| At 1 month |
47 |
105(40) |
46 |
121(73) |
--- |
| At 1.5 month |
47 |
106(44) |
45 |
116(48) |
--- |
| At 2 months |
47 |
104(42) |
45 |
113(50) |
--- |
| At 2.5 months |
45 |
101(40) |
44 |
113(49) |
--- |
| At 3 months |
46 |
103(30) |
45 |
119(57) |
0.062 |
| Same CsA regimen: |
|
||||
| At 4 months |
45 |
105(29) |
44 |
123(46) |
--- |
| At 5 months |
47 |
110(29) |
44 |
126(47) |
--- |
| At 6 months |
47 |
107(28) |
45 |
128(72) |
0.065 |
| At 9 months |
47 |
116(33) |
45 |
131(49) |
--- |
| At 12 months |
46 |
121(36) |
45 |
132(49) |
0.2 |
| †P value of the global test (likelihood ratio test) for treatment effect after three months = 0.162 | |||||
| Creatinine clearance | |||||
| 6 months |
27 |
76.7(31.4)** |
33 |
66.1(29.4)** |
NS |
| 12 months |
23 |
72.7(31.7)** |
23 |
66.9(26.1)** |
NS |
| Cystatin C |
|
||||
| 3 months |
36 |
1.21(0.44)†† |
33 |
1.5(0.7)†† |
0.04 |
| 6 months |
35 |
1.25(0.34)†† |
31 |
1.5(0.9)†† |
NS |
| 12 months | 35 | 1.29(0.40)†† | 30 | 1.4(0.7)†† | NS |
*Creatinine values are expressed as means (SD) in μmol/L, **creatinine clearance values are expressed as means (SD) in mL/min, ††cystatin values are expressed as means (SD) in mg/L.