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. 2012 Jun 8;54(1):35. doi: 10.1186/1751-0147-54-35

Table 1.

Pharmacokinetic variables calculated for doxycycline (10 mg/kg) in dogs through compartmental analysis, after either the IV, PO and SC administration of an aqueous solution, a preparation as tablet or the experimental long acting preparation, respectively

  Doxycycline IV
 Doxycycline PO
 Doxycycline SC
Mean ± SE Mean ± SE Mean ± SE
AUC0-∞ (μg·h/mL)
 97.34 ± 7.45a
 72.89 ± 6.3b
 194.18 ± 12.72c
AUCt (μg·h/mL)
 109.66 ± 8.56a
 70.33 ± 6.23b
 129.70 ± 9.56c
AUMCt (μg·h2/mL)
 909.64 ±23.82a
 820.11 ± 18.63b
 10453.52 ± 135.78c
RT (h)
 10.10 ± 1.12a
 10.22 ± 2.21a
 166.63 ± 5.58b
K½ab (h)
 -
 1.49 ± 0.07
 -
K½el (h-1)
 2.87 ± 0.02a
 5.59 ± 0.03b
 45.21 ± 0.74c
A (h-1)
 14.99 ± 0.11a
 -
 2.16 ± 0.03b
B (h-1)
 8.50 ± 0.07a
 -
 0.86 ± 0.01b
α (h-1)
 2.49 ± 0.02a
 -
 0.07 ± 0.004b
β (h-1)
 0.09 ± 0.003a
 -
 0.005 ± 0.001
T½α (h-1)
 0.28 ± 0.01
 -
 9.30 ± 0.36 b
T½β (h-1)
 7.44 ± 0.06 a
 -
 133.61 ± 6.32 b
Vdc (L/kg)
 6.37 ± 0.76
 -
 -
Vdarea (L/kg)
 1.49 ± 0.27
 -
 -
Vdss (L/kg)
 11.34 ± 1.24
 -
 -
Cs0 (μg/mL)
 23.54 ± 4.32
 -
 -
Cmax (μg/mL)
 -
 5.58 ± 0.5a
 2.8 ± 0.3b
Tmax (h)
 -
 3.88 ± 0.4a
 2.11 ± 0.12b
ClB (mL/kg · h-1)
 134 ± 8
 -
 -
F (%)* - 74.88 199.48

a,b,c,dThe values within a row with no common superscript differ significantly (P < 0.05).

AUC0-∞ = area under the concentration-time curve from zero up to ∞ with extrapolation of the terminal phase; AUMC = area under the first moment of the concentration-time curve; AUCt = area under the concentration-time curve calculated by the trapezoidal method; AUMCt = area under the first moment of the concentration-time curve calculated by the trapezoidal method; RT = retention time; K½el = elimination half rate constant from the central compartment; K½ab = absorption half rate constant from the central compartment; A, B, = zero time intercepts of the distribution and post-distribution phases; α and β = hybrid rate constants for the distribution and elimination phases, respectively; T½β = half-life of the elimination; Vdc= volume of the central compartment; Vdarea= Volume calculated by the area method; Vdss = apparent volume of distribution at steady-state; Cs0 = calculated maximum plasma concentration at zero time; Cmax = calculated maximum plasma concentration; Tmax = time of maximum plasma concentration; ClB = clearance from the body; F = bioavailability.