Table 8.
Risk of severe disease in patients with Plasmodium knowlesi malaria using the recommended cut-offs – multivariate modeling
| Variable | Uncomplicated malaria n (%) | Severe malaria n (%) | Adjusted odds ratio (95c% CI) | p-value† | |
|---|---|---|---|---|---|
| Parasite count (parasites/μl) |
<35000 |
79 (71.8) |
6 (35.3) |
1 |
0.0001 |
| ≥35000 |
14 (28.2) |
11 (64.7) |
9.93 (2.91 – 33.87) |
||
| Parasite count (% IRBC) |
<1 |
73 (78.5) |
6 (35.3) |
1 |
0.003 |
| ≥1 |
20 (21.5) |
11 (64.7) |
5.72 (1.78 – 18.37) |
||
| Platelet count (x 103 platelets/μl) |
>45 |
67 (72) |
5 (29.4) |
1 |
0.004 |
| ≤45 | 26 (28) | 12 (70.6) | 5.27 (1.59 – 17.41)* |
95% CI 95% confidence interval.
% IRBC % infected red blood cells.
†All p-values were obtained from likelihood ratio test.
*The odds ratio was obtained by including the platelet count into one model with parasite count (% IRBC) measured on thin blood films.