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. 2012 Apr 26;11:29. doi: 10.1186/1476-069X-11-29

Table 4.

Phthalates Metabolites and Phenols Urinary Concentrations Among Pregnant Women From Eden and Pélagie Cohorts, France, 2002-2006

 
  
 Correction/standardization applied to the biomarker concentrations
  
 
  
 No correction
(Crude concentrations, μ g/l)a (1)
 Case – control sampling only ( μ g/l)a (2)
 Case – control sampling and creatinine
( μ g/g Cr)b (3)
 Correction for case – control sampling and standardization for sampling conditions including creatinine c ( μ g/l)a (4)
 Correction for case – control sampling and standardization for sampling conditions excluding creatinine d ( μ g/l)a (5)
 Median change
(5 – 2)e
 Correlation standardized – unstandardized (5)(2) f
Compound n Median 25th 75th Median 25th 75th Median 25th 75th Median 25th 75th Median 25th 75th    
Phthalate monoester metabolites
  MEHHP + MEOHP + MECPP + MEHP ( μ mol/l)
 287
 0.36
 0.18
 0.62
 0.37
 0.17
 0.61
 0.32
 0.19
 0.53
 0.53
 0.29
 0.86
 0.58
 0.32
 1.06
 + 56%
 0.94
  MiBP
 287
 50
 29
 97.5
 45.9
 30.2
 84.0
 45.7
 28.0
 71.9
 59.2
 39.0
 101.5
 64.7
 41.2
 119.3
 + 41%
 0.94
  MBP
 287
 57.5
 30.5
 104
 48.1
 28.9
 86.7
 48.5
 27.6
 75.5
 57.5
 35.9
 86.4
 58.1
 34.3
 105.6
 + 21%
 0.96
  MCCP
 287
 2.40
 1.40
 4.80
 2.20
 1.30
 4.30
 1.93
 1.37
 3.20
 2.74
 1.76
 4.91
 3.15
 1.69
 5.54
 + 43%
 0.94
  MBzP
 287
 18.5
 10.4
 40.3
 17.7
 9.3
 33.5
 16.0
 8.6
 28.0
 20.4
 9.7
 42.9
 21.7
 9.6
 57.7
 +23%
 0.88
  MEP
 287
 112
 49.0
 236
 110
 53.3
 215
 106
 54.4
 198
 103
 58.7
 196
 105
 53.9
 240
 − 5%
 0.95
  MCNP
 287
 1.90
 1.10
 3.40
 1.70
 1.10
 3.00
 1.59
 1.15
 2.51
 2.89
 2.05
 5.00
 3.06
 1.89
 5.63
 +80%
 0.95
  MCOP
 287
 3.10
 1.50
 6.20
 2.70
 1.40
 5.10
 2.37
 1.44
 4.58
 3.81
 2.04
 7.39
 3.89
 2.12
 7.93
 +44%
 0.93
Phenols
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  2,4-DCP
 191
 0.90
 0.50
 1.60
 0.90
 0.50
 1.50
 0.78
 0.51
 1.48
 0.78
 0.47
 1.51
 0.77
 0.49
 1.59
 − 14%
 0.98
  2,5-DCP
 191
 10.30
 4.10
 26.8
 10.2
 4.10
 26.50
 8.88
 4.27
 24.4
 6.73
 3.08
 23.3
 6.37
 2.92
 25.6
 − 38%
 0.95
Sum of Parabens ( μ mol/l)
 191
 0.90
 0.28
 2.36
 0.86
 0.27
 2.45
 0.81
 0.29
 2.15
 0.86
 0.30
 2.31
 0.95
 0.29
 2.32
 +10%
 0.98
  BP3
 191
 1.60
 0.60
 4.10
 1.70
 0.70
 4.40
 1.63
 0.64
 4.19
 1.13
 0.59
 3.87
 1.30
 0.54
 4.04
 − 24%
 0.96
  BPA
 191
 2.80
 1.60
 4.90
 2.70
 1.70
 5.50
 2.50
 1.62
 4.49
 3.06
 1.80
 5.26
 3.11
 1.92
 6.11
 +15%
 0.95
  Triclosan 191 24.8 4.0 174 24.1 3.80 173 26.7 3.20 168.1 18.1 2.50 96.2 17.5 2.62 101.1 − 27% 0.99

We applied correction factors of 0.66 and 0.72 to the monoethyl phthalate (MEP) and monobenzyl phthalate (MBzP) concentrations, respectively, because the analytic standards used were of inadequate purity.

a For metabolites of DEHP and sum of parabens, concentrations are reported in μ mol/l.

b For metabolites of DEHP and sum of parabens, corrected concentrations are reported in μ mol/g Creatinine. Correction for creatinine was performed by dividing biomarker concentrations by creatinine concentration.

c Results corrected for over-representation of cases according to Richardson et al. (2007) and standardized for all sampling conditions (including creatinine) using formula (1) in the methods section.

d Results corrected for over-representation of cases according to Richardson et al. (2007) and standardized for sampling conditions (excluding creatinine) using formula (1) in the methods section.

e Relative changes in the median concentration of urinary biomarkers between the estimates of column (5) and (2).

f Coefficient of correlation (Pearson) between non-standardized biomarkers levels corrected for the case – control sampling and concentrations corrected for the case – control sampling and standardized for all sampling conditions excluding creatinine.