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. 2012 Jun 26;120(12):1000–1007. doi: 10.1111/j.1600-0463.2012.02929.x

Table 2.

HER2 amplification measured by IHC by two observers, FISH, and real-time PCR on laser microdissected cancer cells from ovarian carcinoma

Case no. Stage Tumor type IHC FISH HER2/Chr 17 Ratio DNA HER2/Gastrin N = 1–4
1 I Endometrioid 0 1.11 1.48 [0.12–3.48] N = 31
2 I Endometrioid 0 1.20 0.63 [0.62–0.64] N = 2
3 I Papillary serous 1 3.14 2.84 [0.47–5.20] N = 21
4 I Clear cell 0 1.03 0.33 [–] N = 1
5 I Mucinous 0 1.07 0.93 [0.66–1.36] N = 4
6 I Endometrioid 0 1.19 0.61 [0.42–0.80] N = 2
7 I Mucinous 0 1.22 0.20 [0.16–0.35] N = 3
8 I Endometrioid 1 1.23 4.06 [0.94–7.40] N = 31
9 I Papillary mucinous 0 1.43 0.49 [0.40–0.57] N = 3
10 I Endometrioid 0 1.09 0.23 [0.10–0.53] N = 3
11 I Mucinous 0 1.11 0.98 [0.47–1.68] N = 3
12 I Clear cell + serous 2 1.65 0.75 [0.44–1.14] N = 3
13 I Clear cell 0 1.74 0.23 [0.18–0.29] N = 3
14 I Serous 0 1.11 Not Det.
15 I Clear cell 1 1.32 Not Det.
16 II Serous 0 1.10) 0.56 [0.02–1.08] N = 4
17 II Clear cell + endometrioid 0 7: 1.71 & 8: 1.22 1.09 [0.18–2.65] N = 31
18 II Endometrioid 0 ND 0.92 [0.40–1.44] N = 2
19 III Papillary serous 0 0.98 0.63 [0.30–0.75] N = 4
20 III Papillary serous 1 1.13 8.10 [–] N = 1
21 III Endometrioid 1 1.15 0.95 [0.53–1.36] N = 2
22 III Clear cell 0 1.23 0.50 [0.07–1.28] N = 4
23 III Serous 0 1.28 2.77 [0.90–6.81] N = 41
24 III Papillary serous 0 1.46 2.95 [0.11–5.78] N = 21
25 III Endometrioid 0 1.85 1.74 [1.36–2.48] N = 41
26 III Papillary serous 0 0.62 0.27 [–] N = 1
27 III Endometrioid 0 0.98 1.14 [0.83–1.65] N = 3
28 III Endometrioid 0 1.18 1.00 [0.94–1.11] N = 4
29 III Serous + endometrioid 1 1.25 2.97 [0.65–8.19] N = 41
30 III Endometrioid 1 2.03 6.82 [0.94–16.33] N = 41
31 III Endometrioid 2 1.22 1.82 [1.61–2.03] N = 21
32 III Endometrioid 0 1.05 ND
33 III Endometrioid 0 1.07 ND
34 III Serous 0 1.2 ND
35 III Serous 0 1.11 ND
36 IV Serous 1 1.03 0.75 [–] N = 1
37 IV Serous 0 1.17 0.78 [–] N = 1
38 IV Clear cell + serous 1 1.28 3.51 [2.37–4.34] N = 2
39 Mucinous 1 1.15 6.21 [1.4–11.0] N = 21
40 IV Endometrioid 0 1.74 ND

FISH, fluorescence in situ hybridization; HER2, human epidermal growth factor receptor type 2; IHC, immunohistochemistry; ND, not determined; PCR, polymerase chain reaction.

1

The qPCR ratio between HER2 and gastrin has values both above and below cutoff.