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. 2012 Dec;11(6):996–1004. doi: 10.1111/j.1474-9726.2012.00870.x

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© 2012 The Authors. Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland

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Fig. 1 — Purkinje neurons in old (32 months) but not in young (4 months) mice are positive for multiple markers of the senescent phenotype. Representative images are shown. Size marker bars indicate 20 μm. (A–E) Cerebellar sections of mice at the indicated ages were stained with DAPI (blue, nuclei), the neuronal marker calbindin (purple, omitted in E for clarity) and the antibody of interest visualized by IgG-FITC (green). Shown are the antibody of interest (left) and the merged image (right). (A) γH2A.X, (B) activated p38MAPK, (C) 4-hydroxynonenal (4-HNE, a marker for lipid peroxidation), (D) IL-6, (E) mH2A. (F) Autofluorescence on unstained sections. (G) sen-β-Gal activity. Positive cells show blue cytoplasmic staining.