Table 3.
Selected clinicopathological characteristics, gene profiling and survival data for patients harboring EGFRmutations
| Age | Gender | Histology | Smoking status | Treatment Line | cMET (IHC) | EGFR (HIRSCH) | EGFR(FISH) | MET(FISH) | D7S486(FISH) | Best Response | PFS (months) | Survival (months) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
37 |
Female |
AdenoCa |
Smoker |
1st |
ND |
ND |
ND |
ND |
ND |
SD |
12.59 |
25.48 |
| 2 |
56 |
Male |
AdenoCa |
Smoker |
4th |
ND |
ND |
ND |
ND |
ND |
PD |
2.39 |
4.23 |
| 3 |
76 |
Male |
Squamous |
Smoker |
2nd |
ND |
ND |
ND |
ND |
Deletion |
PR |
11.67+ |
11.67+ |
| 4 |
64 |
Male |
AdenoCa |
Non-smoker |
2nd |
Negative |
Negative |
Negative |
Negative |
Deletion |
NE |
8.52 |
29.51 |
| 5 |
76 |
Female |
AdenoCa |
Non-smoker |
1st |
Negative |
Negative |
ND |
Negative |
Normal |
SD |
12.69 |
23.38 |
| 6 |
78 |
Female |
AdenoCa |
Non-smoker |
1st |
Negative |
Negative |
Negative |
Negative |
Normal |
PR |
20.52 |
21.34 |
| 7 |
67 |
Male |
AdenoCa |
Smoker |
2nd |
Negative |
Negative |
Negative |
Negative |
Normal |
PD |
3.25 |
28.49 |
| 8 |
62 |
Female |
AdenoCa |
Non-smoker |
1st |
Positive |
Positive |
Positive |
Negative |
Normal |
SD |
40.20+ |
40.20+ |
| 9 |
47 |
Male |
AdenoCa |
Smoker |
2nd |
ND |
ND |
ND |
ND |
ND |
NE |
4.00 |
4.00 |
| 10 |
43 |
Female |
AdenoCa |
Non-smoker |
2nd |
ND |
ND |
ND |
ND |
ND |
PD |
2.56 |
2.85 |
| 11 | 63 | Male | Squamous | Smoker | 2nd | ND | ND | ND | ND | ND | PD | 2.26 | 12.49 |
ND: not done; NE: non-evaluable.