Table 4.
Association of disease control rate (DCR) with examined biomarkers
| |
|
Response |
||
|---|---|---|---|---|
| |
|
Disease control |
Disease progression |
p-value |
| N (%) | N (%) | |||
|
Gene status |
|
|
|
|
|
KRAS (N=30) |
WT |
7 (0) |
20 (87) |
0.999 |
| |
Mutated |
0 (0) |
3 (13) |
|
|
EGFR (N=33) |
WT |
1 (17) |
21 (78) |
0.010 |
| |
Mutated |
5 (83) |
6 (22) |
|
|
IHC |
|
|
|
|
| EGFR (HIRSCH) (N=45) |
Negative |
8 (73) |
30 (88) |
0.337 |
| |
Positive |
3 (27) |
4 (12) |
|
| pEGFR (N=43) |
Negative |
4 (36) |
15 (47) |
0.728 |
| |
Positive |
7 (64) |
17 (53) |
|
| cMET (N=42) |
Negative |
5 (50) |
17 (53) |
0.999 |
| |
Positive |
5 (50) |
15 (47) |
|
|
FISH |
|
|
|
|
|
EGFR (N=45) |
Negative |
5 (56) |
34 (94) |
0.005 |
| |
High polysomy |
2 (22) |
0 (0) |
|
| |
Amplified |
2 (22) |
2 (6) |
|
|
EGFR (N=45) |
Negative |
5 (56) |
34 (94) |
0.010 |
| |
Positive |
4 (44) |
2 (6) |
|
|
D7S486 (N=37) |
Deletion |
3 (43) |
12 (40) |
0.999 |
| |
Normal |
4 (57) |
18 (60) |
|
|
MET (N=43) |
Negative |
11 (100) |
31 (97) |
0.999 |
| Positive | 0 (0) | 1 (3) | ||