Table 8.
Breast cancer odds ratios (matched analysis) in selected major sectors on tumor estrogen receptor status, and with interaction on prior farm work
| Tumor receptor status | ER+/PR+ | ER+/PR- | ER- |
|---|---|---|---|
| N cases (total=1006) |
538 |
157 |
188 |
|
Model 1 – Cumulative exposure,1no interactions | |||
| |
OR (95% CI) Wald P (two-tailed) |
||
| Farming |
1.32 (0.94-1.85) 0.12 |
1.35 (0.73-2.49) |
1.71 (1.12-2.62) 0.014 |
| Metalworking |
2.03 (1.11-3.71) 0.022 |
1.73 (0.77-3.89) |
1.02 (0.36-2.89) |
| Bars, gambling |
3.87 (1.39-10.8) 0.010 |
3.24 (0.44-24.1) |
0.15 (0.00-4.27) |
| Auto industry: plastics |
3.63 (1.90-6.94) 9×10-5 |
1.17 (0.28-4.97) |
1.76 (0.78-3.94) |
| Canning |
1.50 (0.55-4.10) |
4.01 (1.37-11.8) 0.011 |
3.19 (1.16-8.75) 0.024 |
|
Model 2 – Cumulative exposure with prior farm interaction terms (IpAg) | |||
| |
OR (95% CI) Wald P (two-tailed) |
||
| Farming |
1.32 (0.93-1.87) |
1.34 (0.70-2.57) |
1.76 (1.13-2.74) 0.012 |
| Metalworking |
2.21 (1.14-4.30) 0.019 |
1.51 (0.65-3.50) |
1.17 (0.43-3.13) |
| Metalworking … IpAg |
0.84 (0.53-1.32) |
1.26 (0.95-1.67) 0.11 |
0.47 (0.12-1.93) |
| Bars, gambling |
2.87 (0.93-8.84) 0.066 |
2.78 (0.35-22.1) |
0.20 (0.01-5.45) |
| Bars, gambling … IpAg |
3.03 (0.74-12.4) 0.12 |
3.46 (0.27-45.0) |
0.00 (0.00->100) |
| Auto industry: plastics |
3.13 (1.62-6.05) 7×10-4 |
1.26 (0.30-5.32) |
0.96 (0.31-2.99) |
| Auto plastics… IpAg |
2.10 (0.52-8.43) |
0.65 (0.03-15.3) |
3.03 (0.80-11.6) 0.10 |
| Canning |
1.52 (0.51-4.51) |
1.21 (0.26-5.60) |
4.85 (1.25-18.8) 0.022 |
| Canning… IpAg | 0.91 (0.51-1.65) | 1.81 (1.08-3.04) 0.025 | 0.62 (0.22-1.72) |
Odds ratios (OR) by conditional logistic regression with terms for reproductive, demographic risk factors as in Table 4 and terms for employment duration; matching on age in 3-year intervals; models include all major sector exposures; IpAg, interaction with farming: cumulative (sector rating × prior cum. exposure in agriculture); breast cancer cases not of the specified receptor type were excluded from analysis.
OR for cumulative exposure evaluated at 10.0 year in high-exposed jobs (lagged 5 year) or, for interactions, at 10 years in high-exposed jobs and 1 year in prior high-exposed farm work.