Table 1.
Effect of coenzyme Q10 (CoQ10) on percent of animal mortality, kidney/body weight ratio, blood urea nitrogen (BUN), and creatinine in doxorubicin- (Dox-) induced nephrotoxicity in rats.
| Groups | Mortality % | Kd/Wt | BUN (mg/dL) |
Creatinine (mg/dL) |
|---|---|---|---|---|
| Control | 0 | 5.9 ± 0.8 | 8 ± 1 | 0.95 ± 0.04 |
| CoQ10L | 0 | 5.9 ± 0.6 | 8 ± 2 | 0.9 ± 0.1 |
| CoQ10H | 0 | 6.4 ± 0.7 | 10 ± 1 | 0.9 ± 0.1 |
| Dox | 40a | 7.2 ± 0.6a | 358 ± 97a | 2.6 ± 0.3a |
| Dox/CoQ10L | 25 | 6.7 ± 0.8 | 31 ± 7 b | 1.7 ± 0.1b |
| Dox/CoQ10H | 8 | 6.8 ± 1.1 | 98 ± 31c | 1.9 ± 0.2c |
CoQ10L and CoQ10H are rats treated with low and high doses of CoQ10, respectively; Kd/Wt is kidney/body weight ∗ 1000 ratio. Values are representation of 6–11 observations as means ± SEM, except survival which is represented as a percentage. aSignificant difference compared to control, bsignificant difference compared to Dox group, with no statistically significant difference compared to control, and csignificant difference compared to Dox group, but with also significant difference compared to control group. Results are considered significantly different when P < 0.05.