Figure 1. Effect of diclofenac on action potentials in canine right ventricular muscle preparations and in Purkinje fibers.

Representative superimposed records (top) demonstrating the effect of 20 µM diclofenac on action potential configuration at 1 s stimulation cycle length (A, right ventricular muscle; B, Purkinje fiber). Cycle length dependent changes in action potential duration (APD₉₀) measured under control conditions and in the presence of 20 µM diclofenac (bottom) in canine right ventricular muscle preparations (A) and in Purkinje fibers (B). Data are expressed as mean ± SEM, n = number of measurements/number of animals.