Figure 2. Effect of diclofenac on action potential repolarization in canine right ventricular preparations with impaired repolarization reserve.

(A) Representative superimposed action potentials recorded from canine right ventricular muscle preparation at cycle length of 1 s. In these experiments 30 µM BaCl₂ was applied to attenuate the repolarization reserve prior to 20 µM diclofenac superfusion. (B) Cycle length dependent changes in APD₉₀ measured under the specified experimental conditions in canine right ventricular muscle preparation. Data are expressed as mean ± SEM, n = number of measurements/number of animals.