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. 2012 Dec 31;7(12):e53255. doi: 10.1371/journal.pone.0053255

Figure 3. Effect of diclofenac on repolarization and TdP incidence in anesthetized rabbits.

Figure 3

(A) Frequency corrected QT intervals (QTc) and (B) incidence of Torsades de Pointes ventricular tachycardia (TdP) in anaesthetized rabbits before and following dofetilide (25 µg/kg), dofetilide+diclofenac (3 mg/kg) and diclofenac, diclofenac+dofetilide administration. *p<0.05 vs. control, +p<0.05 vs. diclofenac, §p<0.05 vs. dofetilide, n = 15 and 13 animals/group, respectively. (C) Representative ECG recordings illustrate TdP development only after dofetilide or diclofenac+dofetilide combination, but not following diclofenac administration. #p<0.05 vs. baseline, n = 13 and 15 animals/group, respectively.