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. 2012 Dec 31;7(12):e53569. doi: 10.1371/journal.pone.0053569

Figure 9. GABAergic interneurogenesis in the hilus is sex-dependent in aged apoE-KI mice.

Figure 9

A, Total numbers of BrdU and GABA double-positive cells in the hilus of female and male apoE-KI mice at 16 months of age were determined 1 month after BrdU injection. Values are mean ± SE (n = 6−8 mice per group). *p<0.05 in 16-month-old male apoE4-KI mice compared to their female counterparts (post-hoc Bonferroni test); **p<0.01 in older male apoE3-KI mice compared to their female counterparts at the same age (post-hoc Bonferroni test). B, D, Images of the hilus of 16-month-old male apoE3-KI mice stained with anti-BrdU (red) and anti-GABA (green) collected 1 month after BrdU injection (magnification: B, 100x; D, 200x). C, E, Images of the hilus of 16-month-old male apoE4-KI mice stained with anti-BrdU (red) and anti-GABA (green) collected 1 month after BrdU injection (magnification: C, 100x; E, 200x).