Skip to main content
. 2012 Dec 31;7(12):e53050. doi: 10.1371/journal.pone.0053050

Figure 6. Schematic representation of major CDCP1 features important for focus formation.

Figure 6

Only upon overexpression of Src and CDCP1, cells become transformed, and all changes in CDCP1 except for the processing mutant reduce transformation efficiency. (A–K) Left line, CDCP1 with five intracellular tyrosine residues (circles below horizontal line that represents the plasma membrane), right line with circle, Src kinase; fat print, overexpression; filled circles, tyrosine residues phosphorylated upon transient overexpression. X - no focus formation; arrows indicate focus formation. (D) mutant Y734F, (E) addback mutant Y734, (F) mutant C689, 690G, (G) mutant ΔNT217, (H) mutant ΔNT370, (I) mutant K365A, R368A, (K) myristoylation defective Src G2A mutant.