Table 2. Results of computational analysis for missense changes in ABCD1 gene from Argentinean patients.

Missense Change	p.Ala19Ser	p.Tyr547Cys	p.His420Pro	p.His669Arg	p.Ala341Asp
Multiple sequence alignment MSA	Highly conserved	Highly conserved	Relatively conserved	Conserved	Highly conserved
http://www.ebi.ac.uk/clustalw2/
SIFT	Tolerated	Non-tolerated	Tolerated	Tolerated	Non-tolerated
http://blocks.fhcrc.org/sift/SIFT.html
PolyPhen	Benign	Probably damaging	Probably damaging	Benign	Possibly damaging
http://genetics.bwh.harvard.edu/pph