Figure 1. In vivo maturation of VM hNSC transplants.

VM hNSCs (hVM1-Bcl-X_L) were transplanted into the 6-OH-DA lesioned rat striatum for a survival time of 2 months. A–C) Tyrosine hydroxylase immunohistochemistry developed with DAB, showing areas in the graft populated with morphologically immature TH⁺ neurons (B) and others with mature neurons (C), or devoid of them. D, E) Numerous cells in the grafts were still engaged in the cell cycle (Ki-67⁺, panel E) at this survival time. Scale bar in A, E: 500 µm; in B, C: 20 µm.