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. 2012 Dec 31;7(12):e52714. doi: 10.1371/journal.pone.0052714

Table 1. Global account of the results obtained for the different criteria used.

Polyclonal Clone 1 Clone 2 Clone 3 Clone 13 Clone 15 Clone 16 Clone 28 Clone 30 Clone 32
v-myc copies 4 4 2 3 2 1 2 2 1 2
v-myc downregulation + + ++ ++ + +
Ki-67 downregulation ++ + + + ++
Nestin downregulation + + ++ + +
Differentiation to ß-III-tub+ cells + + ++ + ++ + + ++
Differentiation to TH+ cells + + ++ - ++ + + ++
Reduction of Ki-67 in vivo 1 1 1.2 1 2.3 3 1.8 1.5 3 3
hNSE in vivo + nd nd nd nd nd nd nd + +
TH in vivo ++ + + + + + + + +
Rotational compensation + ++ + + + + + + ++ +

Polyclonal = hVM1-Bcl-XL cells. Scoring is presented from low values (−), to one or two (+) signs, being (++) the best result for each parameter. For the in vivo reduction of Ki- 67 staining, grafts were scored for 1 to 3, being 3 the best score indicating cell cycle exit.