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. 2012 Jul 18;6(1):156–166. doi: 10.1038/mi.2012.59

Figure 1.

Figure 1

Effect of the route of immunization on systemic and mucosal p18-specific CD8+ T-cell responses. Mice were immunized by the intramuscular (IM) route with 40 μg of plasmid DNA expressing HIV-1 HXB2 gp120 protein or by the pulmonary route with 40 μg of this DNA formulated with polyethyleneimine (PEI). (a) Kinetics of the p18-specific CD8+ T-cell response in the peripheral blood of immunized mice. p18-specific CD8+ T-cell responses in (b) mediastinal lymph nodes (MLN), (c) pulmonary lymphocytes and (d) broncho-alveolar lavage (BAL) lymphocytes of mice on day 42 following IM immunization with DNA-gp120 or by the pulmonary route with PEI-DNA-gp120. Data represent means of 4–8 mice per group±s.e.