Table II.
Association between rs2296675 and risk of all cancers, overall and stratified by age at baseline
| Additive model | Genotype (n)c | Genotypic and dominant models | |||
|---|---|---|---|---|---|
| OR (95% CI)a | OR (95% CI)b | OR (95% CI)a | OR (95% CI)b | ||
| Overall | 1.30 (1.19–1.43) | 1.25 (1.13–1.39) | AA (3633) | 1.0 (referent) | 1.0 (referent) |
| AG (1912) | 1.38 (1.23–1.55) | 1.33 (1.17–1.51) | |||
| GG (235) | 1.43 (1.08–1.88) | 1.28 (0.94–1.74) | |||
| AG + GG | 1.38 (1.24–1.55) | 1.33 (1.17–1.50) | |||
| Stratified by age at baseline; P-for-interaction = 0.021 (dominant model) | |||||
| Age ≤54 years | 1.37 (1.20–1.57) | 1.34 (1.16–1.55) | AA (1889) | 1.0 (referent) | 1.0 (referent) |
| AG (917) | 1.53 (1.31–1.80) | 1.50 (1.26–1.79) | |||
| GG (101) | 1.28 (0.86–1.92) | 1.24 (0.81–1.92) | |||
| AG + GG | 1.51 (1.29–1.76) | 1.47 (1.24–1.74) | |||
| Age ≥55 years | 1.13 (0.97–1.32) | 1.14 (0.98–1.33) | AA (1745) | 1.0 (referent) | 1.0 (referent) |
| AG (995) | 1.13 (0.93–1.36) | 1.13 (0.94–1.37) | |||
| GG (134) | 1.31 (0.84–2.03) | 1.32 (0.84–2.06) | |||
| AG + GG | 1.14 (0.96–1.37) | 1.15 (0.96–1.38) | |||
aAssociations adjusted for first three principal components to control for potential residual confounding by ancestry.
bAssociations adjusted for first three principal components plus age, sex, education, cigarette smoking, and body mass index.
cNumbers may not sum to 5916 due to genotyping failures.