Table III.
Association between being a carrier of a minor allele in rs2296675 (dominant model: AG + GG versus AA) and risk of (a) all cancers, (b) smoking-caused cancers, and (c) cancers not currently established to be caused by cigarette smoking, stratified by cigarette smoking status at baseline
| Smoking status | Minimally adjusted | Fully adjusted |
|---|---|---|
| OR (95% CI)a | OR (95% CI)b | |
| Total (P-for-interaction = 0.22) | ||
| Never smokers | 1.53 (1.30–1.79) | 1.41 (1.18–1.70) |
| Former smokers | 1.20 (0.98–1.48) | 1.14 (0.91–1.42) |
| Current smokers | 1.43 (1.13–1.80) | 1.45 (1.13–1.86) |
| Smoking-caused cancers (P-for-interaction = 0.43) | ||
| Never smokers | 1.50 (1.09–2.07) | 1.37 (0.98–1.92) |
| Former smokers | 1.16 (0.86–1.55) | 1.10 (0.81–1.49) |
| Current smokers | 1.47 (1.10–1.82) | 1.49 (1.09–2.03) |
| Cancers not established to be caused by smoking (P-for-interaction = 0.27) | ||
| Never smokers | 1.53 (1.30–1.80) | 1.42 (1.18–1.71) |
| Former smokers | 1.22 (0.98–1.51) | 1.15 (0.91–1.45) |
| Current smokers | 1.39 (1.06–1.82) | 1.41 (1.07–1.88) |
CI, confidence interval; OR, odds ratio.
aAssociations adjusted for first three principal components to control for potential residual confounding by ancestry.
bAssociations adjusted for first three principal components plus age, sex, education, and body mass index.