Table IV.

Associations between rs2296675 and risk of specific malignancies

Types of cancer	# cases	Minimally adjusted		Fully adjusted
		OR (95% CI)a	P valuea	OR (95% CI)b	P valueb
Nonmelanoma skinc	694	1.23 (1.03–1.48)	0.02	1.15 (0.94–1.40)	0.17
Breast	527	1.45 (1.19–1.76)	0.0002	1.58 (1.27–1.97)	6.6×10−5
Prostate	483	1.28 (1.01–1.61)	0.04	1.04 (0.79–1.37)	0.80
Lung	332	1.48 (1.16–1.86)	0.002	1.16 (0.88–1.51)	0.29
Colorectal	292	1.54 (1.18–2.00)	0.002	1.33 (1.00–1.78)	0.054
Melanoma	197	1.36 (1.00–1.85)	0.048	1.31 (0.96–1.80)	0.09
Bladder	130	1.47 (1.03–2.11)	0.04	1.08 (0.73–1.59)	0.72
Uterus	113	1.47 (0.99–2.18)	0.057	1.51 (0.99–2.30)	0.055
Lymphoma	89	1.41 (0.92–2.18)	0.12	1.31 (0.84–2.05)	0.23
Cervix	83	1.32 (0.84–2.08)	0.23	1.33 (0.83–2.13)	0.23
Ovary	74	1.22 (0.75–2.00)	0.42	1.28 (0.76–2.14)	0.35
Pancreas	72	1.57 (0.98–2.53)	0.06	1.39 (0.85–2.27)	0.19
Leukemias	69	1.80 (1.11–2.91)	0.02	1.59 (0.97–2.61)	0.06
Kidney/urinary tract	62	2.01 (1.20–3.34)	0.008	1.74 (1.03–2.94)	0.04
All other malignanciesd	403	1.28 (1.03–1.59)	0.03	1.13 (0.90–1.43)	0.30

CI, confidence interval; OD, odds ratio.

^aResults for dominant model (AG + GG versus AA genotypes). All associations adjusted for first three principal components to control for potential residual confounding by ancestry.

^bAssociations adjusted for first three principal components plus age, sex, education, cigarette smoking, and body mass index.

^cThis group is comprised of those whose only cancer diagnosis was non-melanoma skin cancer.

^dThis group includes all remaining cancer cases not included in the above categories.