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Total tobacco consumption, and nicotine’s metabolic profile, differed between (A) NMR strata and (B) CYP2A6 genotypes in cigarette smokers (n = 141). The total size of pie charts represents the amount of urinary TNE. The percentage of TNE recovered as each nicotine metabolite is represented by the size of the section. Cotinine and its subsequent metabolites are represented by the darker shades, nicotine and the remaining metabolites are represented by the lighter shades.
