Table 1.
List of interactions between human casein kinase 1α and substrate p53 tumour suppressor transactivation domain
| Residues in the crystal structure of p53 transactivation domain | Substrate interacting residues of human casein kinase 1α | Nature of interaction |
|---|---|---|
| E17 |
R214, K260, G251 |
Ionic interaction |
| T18 |
T212 |
Hydrogen bonding |
| F19 |
K260 |
Cation-π interaction |
| D21 |
K138 |
Ionic interaction |
| K24 |
D136 |
Ionic interaction |
| L25 |
F28 |
Hydrophobic interaction |
| P27 |
A52, P55 |
Hydrophobic interaction |
| E28 | R135 | Ionic interaction |