Table 2.
List of dimer interface residues in PKR and the nature of interactions between them
| PKR (B chain) | PKR (C chain) | Nature of interaction |
|---|---|---|
| R262 |
D266 |
Ionic interaction |
| D266 |
R262 |
Ionic interaction |
| H286 |
C326 |
Hydrogen bond : NE2 of His with O of Cys |
| I288 |
Y300, V309 |
Hydrophobic interaction |
| D289 |
Y323 |
Hydrogen bond: OD2 of asp with OH of Tyr |
| Y293 |
Y323 |
Hydrophobic interaction |
| D316 |
H322 |
Ionic interaction, |
| V318 |
V318 |
Hydrophobic interaction |
| H322 |
D316,Y323 |
Hydrogen bond: ND1 of his with OD1 of Asp |
| NE2 of his with OD1 of Asp | ||
| NE2 of his with O of Tyr | ||
| Ionic interaction | ||
| Y323 |
Y293, H322,D289 |
Hydrophobic interaction |
| Hydrogen bond : O of Tyr with NE2 of His | ||
| OH of Tyr with OD2 of Asp | ||
| N324 |
Y323,N324 |
Hydrogen bond: ND2 of Asn with O of Tyr |
| ND2 of Asn with O of Asn | ||
| C326 | H286 | Hydrogen bond: SG of Cys with NE2 of His |