Figure 1.

Interaction effects between instrumental ADL and cognitive outcomes. Six-month mean Instrumental Activities of Daily Living (IADL) scale outcomes with 95% confidence intervals predicted by the general linear models for patients with IADL scores of: a. 12, b. 16 and c. 20 at the start of ChEI treatment. A significant interaction effect was observed between cognitive and functional abilities at baseline (p = 0.002), i.e., a higher level of cognition and more impaired ADL ability implied increased response to ChEI therapy. In the figures, the calculated outcomes were based on a 75-year-old patient, and Mini-Mental State Examination (MMSE) scores (15, 20 and 25 were chosen as arbitrary examples) were used to illustrate the interaction.