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. 2012 Oct 23;68(1):82–90. doi: 10.1136/thoraxjnl-2012-202003

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Interleukin (IL)-25 acts directly on mesenchymal cells to induce remodelling. (A) Activin A quantification in lung homogenate. (B) Biologically active pulmonary transforming growth factor (TGF)-β levels. (C) IL-25-induced extracellular collagen secretion by normal human lung fibroblasts (NHLFs) in vitro. (D) IL-17RB (brown stained) lung section: (i) negative Ig control; (ii)–(iv) IL-17RB-positive cells. *p<0.05 compared with phosphate-buffered saline (PBS) control group. §p<0.05 AdS house dust mite (HDM) Ig compared with AdC HDM Ig control group. †p<0.05 HDM anti-IL-25 compared with HDM Ig control group. Plots depict the median and IQR and minimum and maximum values. Data are generated from two independent experiments (n=8–12). IHC, immunohistochemistry. This figure is only reproduced in colour in the online version.